Niclosamide Bolus 1250 mg
Niclosamide Bolus inodzivirira phosphorylation mu mitochondria yecestodes. Mukati memuviri wemunhu uye mumuviri wemunhu, zvikamu zve scolex neproximal zvinourayiwa kana zvasangana nemushonga. Scolex yakasunungurwa inogona kugayiwa muura; saka, zvingave zvisingaite kuziva scolex iri mutsvina. Niclosamide Bolus inoshanda ne taenicidal uye inobvisa kwete zvikamu chete asiwo scolex.
Kushanda kweNiclosamide Bolus kurwisa honye kunoita sekunge kuri nekuda kwekudziviswa kwe phosphorylation ye mitochondrial oxidative; kugadzirwa kweATP isina aerobic kunokanganiswawo.
Basa reNiclosamide Bolus mumasero eropa (cestocidal activity) rinokonzerwa nekudziviswa kwekutorwa kweglucose ne tapeworm uye nekusunungurwa kwe oxidative phosphorylation process mu mitochondria ye cestodes. Lactic acid yakaunganidzwa inobva mukuvharirwa kweKrebs cycle inouraya honye.
Zviratidzo
Niclosamide Bolus inoratidzwa muzvirwere zvehonye dzemhuka, huku, imbwa nekatsi uye zvakare muzvirwere zveparamphistomiasis (Amphistomiasis) zvemombe, makwai nembudzi.
Makonye emudumbu
Mombe, Makwai Mbudzi neMhara: Mhando dzeMoniezia Thysanosoma (Fringed Tape worms)
Imbwa: Dipylidium Caninum, Taenia Pisiformis T. hydatigena uye T. taeniaeformis.
Mabhiza: Utachiona hweAnoplocephalid
Huku: Raillietina naDavainea
Amphistomiasis: (Zviratidzo Zvisati Zvakura)
Mumombe nemakwai, maRumen fluke (mhando yeParamphistomum) akajairika. Kunyange zvazvo maRumen fluke makuru akabatana nemadziro erumen angasanyanya kukosha, aya asina kukura anokonzera kukuvara kukuru uye kufa paanenge achitamira mumadziro eduodenal.
Mhuka dzine zviratidzo zvekusada kudya zvakanyanya, kunwa mvura yakawanda, uye manyoka ane nhumbu dzinofanira kufungidzirwa kuti dzine amphistomiasis uye dzinofanira kurapwa nekukurumidza neNiclosamide Bolus kudzivirira kufa nekurasikirwa nekubereka sezvo Niclosamide Bolus ichigara ichipa simba rakawanda pakurwisa zvipembenene zvisina kukura.
Kuumbwa
Bolus imwe neimwe isina kuputirwa ine:
Niclosamide IP 1.0 gm
Kutarisirwa uye chipimo chemushonga
Niclosamide Bolus mukudya kana zvakadaro.
Kurwisa Makonye
Mombe, Makwai neMabhiza: 1 gm bolus yehuremu hwemuviri hwe20 kg
Imbwa neKatsi: 1 gm bolus yehuremu hwemuviri hwe10 kg
Huku: 1 gm bolus yeshiri huru shanu
(Inenge 175 mg pa kg yehuremu hwemuviri)
Kupesana neAmphistomes
Mombe neMakwai:Chipimo chakakwira pamwero we 1.0 gm bolus / 10 kg yehuremu hwemuviri.
Kuchengetedzeka:Niclosamide bolus ine njodzi yakakura. Kunwa Niclosamide zvakanyanya ka40 mumakwai nemombe kwakaonekwa kuti hakuna chepfu. Mumbwa nekatsi, chipimo chinokurudzirwa kaviri hachikonzeri matambudziko kunze kwekupfava kwetsvina. Niclosamide bolus inogona kushandiswa zvakachengeteka muzvikamu zvese zvepamuviri uye kune vanhu vakaremara pasina migumisiro yakaipa.
