Nicolosamide Bolus 1250 mg
Niclosamide Bolus inhibits phosphorylation mumitochondria ye cestodes.Zvese zviri zviviri in vitro uye in vivo, iyo scolex uye proximal zvikamu zvinourawa pakubata nemushonga.Iyo yakasunungurwa scolex inogona kugayiwa muura;saka, zvingave zvisingaiti kuziva scolex mutsvina.Niclosamide Bolus ndeye taenicid mukuita uye inobvisa kwete zvikamu chete asiwo scolex.
Niclosamide Bolus basa rekurwisa makonye rinoratidzika kunge rakakonzerwa nekuvharirwa kwemitochondrial oxidative phosphorylation;Anaerobic ATP kugadzirwa kunokanganisa zvakare.
Iyo cestocidal chiitiko cheNiclosamide Bolus imhaka yekuvharirwa kwekutorwa kweglucose netapeworm uye kune kubatanidzwa kweiyo oxidative phosphorylation process mumitochondria yecestodes.Iyo yakaunganidzwa lactic acid inokonzerwa nekuvharika kweKrebs cycle inouraya makonye.
Zviratidzo
Niclosamide Bolus inoratidzwa mune zvese zviri zviviri tapeworm kuzara kweZvipfuyo, Huku, Imbwa neKatsi uye zvakare mune immature paramphistomiasis (Amphistomiasis) yemombe, Makwai nembudzi.
Tapeworms
Mombe, Makwai Mbudzi nemhembwe: Moniezia Species Thysanosoma (Fringed Tape worms)
Imbwa: Dipylidium Caninum, Taenia Pisiformis T. hydatigena uye T. taeniaeformis.
Mabhiza: Anoplocephalid zvirwere
Huku: Raillietina naDavainea
Amphistomiasis: (Immature Paramphistomes)
Mumombe neGwai, Rumen flukes (Paramphistomum species) inowanikwa zvakanyanya.Nepo maflue echikuru anonamirwa kumadziro erumen angave asina kukosha zvishoma, iwo asati akura anokonzeresa zvakanyanya kukuvadza uye kufa paanenge achitamira muduodenal wall.
Mhuka dzinoratidza zviratidzo zveanorexia yakanyanya, kuwedzera kunwa mvura, uye manyoka ane mvura anofanirwa kufungidzirwa kuti ane amphistomiasis uye nekukasira kurapwa neNiclosamide Bolus kudzivirira kufa uye kurasikirwa kwekugadzirwa sezvo Niclosamide Bolus ichipa zvinogara zvakanyanya zvakanyanya kurwisa zvipembenene zvisina kukura.
Composition
Imwe neimwe isina kuvharwa bolus ine:
Niclosamide IP 1.0 gm
Administration uye chipimo chemushonga
Nicolosamide Bolus mune zvekudya kana zvakadaro.
Kurwisa Tapeworms
Mombe, Makwai neMabhiza: 1 gm bolus ye20 kg uremu hwemuviri
Imbwa neKatsi: 1 gm bolus ye10 kg uremu hwemuviri
Huku: 1 gm bolus ye5 shiri dzakura
(Inenge 175 mg pakg uremu hwemuviri)
Against Amphistomes
Mombe & Makwai:Yakakwira dosage pachiyero che 1.0 gm bolus / 10 kg uremu hwemuviri.
Safety:Niclosamide bolus ine muganho wakafara wekuchengetedza.Kuwedzeredza kweNiclosamide kanosvika makumi mana mumakwai nemombe kwakawanikwa kusiri chepfu.MuImbwa nekatsi, kaviri dosi yakakurudzirwa haikonzeri zvakaipa kunze kwekupfava kwetsvina.Niclosamide bolus inogona kushandiswa zvakachengeteka muzvikamu zvese zvekuzvitakura uye muzvidzidzo zvakawoma pasina mhedzisiro.
